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Source text - English What is proteome analysis?
Proteome analysis is the investigation of all the proteins present in a cell, tissue or organism at any one time. Since cells are constantly responding to their environment, and the proteins are the workhorses of the cell, the proteome is also changing-reflecting the life of the cell. By using carefully controlled growth conditions, it is possible to obtain exquisitely detailed information about the molecular biology of the living cell and the organism-and for example what happens during disease development.
Why is proteome analysis important-just now?
The central dogma of molecular biology is the relationship between DNA, RNA and proteins:
There are many clear reasons why an understanding of the proteome will be more useful than an understanding of genome. Here are five of them:
1. The genome is the total sum of all the genes in an organism. Normally, every cell in an organism contains an identical copy of the genome. However the information stored in the genome is used differently in different cells in order to produce different types of cell-liver, muscle, bone or blood cells. These differences are due to the proteins that use the genetic information differently in each cell.
2. Nearly all major diseases are caused by an unfortunate combination of a number of genes-perhaps 20 or many more. One needs to study the proteome of affected people to select which 20 or so genes are the important genes (out of the more than 160,000 genes present in the cell).
3. In many human diseases (probably more than 50%), it is an incorrect modification of a normal protein that leads to the development of the disease. These cannot be seen or deduced from the genome.
4. Proteins are almost always useful for diagnosis of disease.
5. The targets for nearly all drugs used for treatment are proteins.
Translation - French Qu’est-ce que l’analyse protéomique ?
L’analyse protéomique désigne l’étude de toutes les protéines présentes dans une cellule, un tissu ou un organisme vivant à un moment donné. Comme les protéines sont les chevilles ouvrières des cellules qui réagissent en permanence à leur environnement, le protéome varie et reflète la vie cellulaire. Dans des conditions de croissance soigneusement contrôlées, il devient ainsi possible d’obtenir des renseignements extrêmement précis à propos de la biologie moléculaire d’une cellule ou d’un organisme vivant et, par exemple, de savoir ce qui se produit lors du développement d’une maladie.
Pourquoi l’analyse protéomique est-elle importante actuellement?
Le dogme central de la biologie moléculaire énonce un lien entre l’ADN, l’ARN et les protéines.
L’étude du protéome est plus utile que celle du génome pour des raisons évidentes, en voici d’ailleurs cinq :
1. Le génome est l’ensemble des gènes portés par un organisme. Normalement, chaque cellule contient l’exacte réplique du génome. Cependant, l’information conservée dans le génome varie d’une cellule à l’autre afin de produire différentes sortes de cellules telles que les cellules hépatiques, musculaires, osseuses ou sanguines. Cette diversité est due aux protéines qui emploient l’information génétique d’une façon différente pour chaque cellule.
2. Presque toutes les maladies majeures sont causées par une combinaison inadéquate de gènes (possiblement 20, peut-être beaucoup plus). Il faut donc étudier le protéome des malades pour trouver les 20 gènes importants parmi les 160 000 gènes et plus que contient une cellule.
3. Probablement plus de 50 % des maladies humaines résultent de la modification inappropriée d’une protéine normale. Cela ne peut ni être vu, ni être déduit du génome.
4. Les protéines sont presque toujours utiles pour diagnostiquer les maladies.
5. Les médicaments qui servent aux traitements visent presque tous les protéines.
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Translation education
Master's degree - university of Paris III
Experience
Years of experience: 19. Registered at ProZ.com: May 2006.
French to Chinese (Université de la Sorbonne Paris 3) Chinese to French (Université de Montréal) Chinese to English (Guangdong University of Foreign Studies) English to Chinese (Guangdong University of Foreign Studies) French to English (Concordia University)
Memberships
N/A
Software
Adobe Acrobat, Microsoft Excel, Microsoft Word, multiterme, logiterme, Powerpoint, Trados Studio, Wordfast
I am a native speaker of Chinese, Cantonese and Taiwanese. I am also an exchange Student from Paris. I am now studying in Montreal for a one-year exchange program. This is a program between Concordia University and l'Université de La Sorbonne.
I am now majored in Translation (French-English) in Montreal, where I learn the translation skill from French to English. I am also learning English to French translation at Université de Montréal. I know how to work with Wordfast and Trados. I take Translation Project Management as one of my courses, from which I know how a translation agency works.
Before coming to Canada, I was living in France for three years. In France, I obtained a BA degree in Trilingual Translation (French-Chinese-English). Moreover, I had my BA degree in English, when I was studying in China. Since I am from Guangdong Province, which is often called Canton, I could speak Cantonese and I could read sophisticated Chinese as well as simplified Chinese.
Expertise 
CV/Resume (DOC)